Genetic Influences on Individual Differences in Nicotine Glucuronidation
نویسندگان
چکیده
منابع مشابه
Genetic influences on individual differences in nicotine glucuronidation.
Nicotine and its primary oxidative metabolites are metabolized in part by glucuronidation. Genetic variation in UGT isoenzymes that catalyze glucuronidation activity suggests that variation in glucuronidation rate is in part genetically determined. The relative contribution of genetic and environmental sources to individual differences in the rate of glucuronidation of nicotine, cotinine, and t...
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We previously reported that the metabolism of cotinine, the proximate metabolite of nicotine, is significantly slower in black than in white cigarette smokers. To understand why the metabolism of nicotine and cotinine might differ between blacks and whites, we studied the pattern of nicotine metabolism in blacks and whites. One hundred eight healthy smokers (51 blacks and 57 whites), of similar...
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ژورنال
عنوان ژورنال: Twin Research and Human Genetics
سال: 2009
ISSN: 1832-4274,1839-2628
DOI: 10.1375/twin.12.5.507